Vaccines not only save lives but are central to global health security and are a fundamental component for achieving several of the United Nations Sustainable Development Goals. But despite the known value of vaccines and great advances in research and development, millions of children still miss out on basic vaccines and global immunisation rates have stalled over the past few years. The All-Party Parliamentary Group on Vaccinations for All, supported by RESULTS UK, conducted an inquiry into the reasons for stalling global immunisation rates, taking written and oral evidence from a variety of stakeholders across the sector. The subsequent report highlights the key challenges that remain and provides recommendations for all immunisation actors and donors for progress in the next decade of vaccines.